Biomolecular Interaction Analysis Platform
Biomolecular interaction analysis is a core technology for drug discovery, characterization, and quality control, enabling label‑free, real-time, quantitative measurement of molecular binding events. Based on Bio-Layer Interferometry (BLI) and Surface Plasmon Resonance (SPR), this platform provides precise kinetic and affinity data including association rate (kₐ), dissociation rate (kd), equilibrium dissociation constant (KD), and binding specificity. It is widely used for biologic development, antibody screening, small‑molecule target validation, vaccine research, and regulatory compliance.
| Technology Type | Core Advantages | Applicable Scenarios |
| BLI | High throughput, fluidics-free, low sample consumption, parallel detection, compatible with crude samples |
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| SPR | Ultra‑high sensitivity, wide affinity range, high precision, microfluidic control, gold standard for kinetic analysis |
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Biomolecular Interaction Analysis Platform
PharmaAnalytica has built a high-performance, compliant, integrated biomolecular interaction platform dedicated to real-time label-free binding analysis, equipped with industry-leading instruments to support robust, traceable, and regulatory-ready testing throughout drug R&D and manufacturing.
Gator Plus BLI System
Gator Plus is an advanced label-free BLI analyzer featuring 8-channel parallel detection, high baseline stability, and optimized signal-to-noise performance. It supports 96/384-well plate compatibility, temperature control (4 °C to 40 °C), and long‑duration walk-away operation up to 6 hours. Capable of processing up to 456 samples per run and supporting 16×16 epitope binning, it delivers rapid, reliable kinetics, affinity, and quantitation data for antibodies, proteins, peptides, nucleic acids, AAV vectors, and small molecules with minimal sample consumption.
MI-S2000F SPR System
MI-S2000F is a high-performance surface plasmon resonance system offering ultra-high sensitivity, excellent stability, and precise microfluidic control. It supports real-time label-free detection over a broad affinity range from weak to ultra-high affinity interactions, delivering accurate kₐ, kd, and KD values. Ideal for small-molecule target validation, antibody characterization, Fc receptor binding analysis, mechanism studies, and biosimilar comparability, it provides high‑quality data for biologic development and regulatory compliance.
Covered Drug Categories for Bioanalysis
Powered by our high-precision biomolecular interaction platform, PharmaAnalytica supports label-free binding analysis and characterization for a full spectrum of drug molecules, advanced therapeutics, and biological macromolecules, covering the entire research and development chain of innovative drugs, biosimilars, and gene therapy products:
- Monoclonal antibodies, bispecific antibodies, antibody fragments
- ADCs, fusion proteins, recombinant proteins, peptides
- Small-molecule inhibitors and target proteins
- Vaccine antigens, VLPs, viral vectors, immune complexes
- Receptors, enzymes, ligands, biomacromolecular complexes
- Nucleic acids, aptamers, glycans, lipids
- AAV vectors and gene therapy products
Core Testing & Application Services
PharmaAnalytica leverages high-performance BLI and SPR technologies to provide comprehensive, compliant, and high-precision testing services across the entire drug lifecycle, covering drug discovery, development, quality control, and regulatory submission:
Drug Discovery & Target Validation
- Real-time label-free measurement of protein-protein, protein-small molecule, protein-peptide interactions
- Target binding verification and affinity screening
- Lead compound optimization and structure–activity relationship (SAR) support
- High-throughput screening of antibodies and small molecules
Biologics Characterization & Development
- Antibody affinity, kinetics, and specificity evaluation
- Epitope binning, mapping, and competitive binding analysis
- FcRn, FcγR, C1q binding kinetics for functional assessment
- Antibody drug conjugation (ADC) linker stability and binding analysis
- AAV capsid titer, empty/full ratio, and vector characterization
Vaccine & Immunotherapeutics
- Antigen-antibody binding affinity and kinetics
- Neutralizing antibody titer and activity determination
- Vaccine candidate screening and immune mechanism study
- VLP, viral vector, and protein assembly characterization
Quality Control & Consistency Evaluation
- Potency testing and product release quantification
- Stability‑indicating binding analysis under stress conditions
- Comparability studies for biosimilars and process changes
PharmaAnalytica's Biomolecular Interaction Analysis Platform provides label-free, real-time, high-precision characterization of molecular interactions across the full drug lifecycle. By delivering accurate ka, kd, KD, and specificity data, the platform supports target validation, lead screening, biologic optimization, vaccine development, and regulatory compliance. Backed by industry‑leading instruments, validated methods, and professional data analysis, we enable accelerated, reliable, and compliant R&D for biologics, small molecules, and gene therapies, ensuring safe, effective, and high-quality drug development.
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