Thermal Analysis Platform
Thermal Analysis (TA), as a core foundational technology for characterizing thermal properties, polymorphism, stability and purity in the pharmaceutical industry, consists of DSC, TGA, STA and integrated systems. It enables non-destructive, high-precision measurement of melting, glass transition, dehydration, decomposition, expansion and deformation behaviors under programmed temperature conditions. DSC is widely used for polymorphism identification, glass transition temperature (Tg) and compatibility studies; TGA quantifies moisture, solvent residues and thermal stability; STA provides simultaneous thermal and mass change data; TMA characterizes thermomechanical properties of dosage forms and excipients. The core functions and applicable scenarios are summarized below:
| Technology Type | Core Advantages | Applicable Scenarios |
| DSC | Melting point, Tg, polymorphism, crystallinity, oxidation induction time (OIT), drug-excipient compatibility |
|
| TGA | Thermal stability, decomposition temperature, moisture / crystal water, volatile components, solvent residues |
|
| STA | Simultaneous DSC-TG detection, phase change and decomposition distinction |
|
Thermal Analysis Platform
PharmaAnalytica has built a fully automated, high-precision integrated thermal analysis platform dedicated to pharmaceutical solid-state characterization and quality control, equipped with high-performance analytical instruments to guarantee standardized, efficient and stable experimental operations.
DZ-DSC103 High-Temperature DSC
DZ-DSC103 features a wide temperature range up to 1500 °C, constantan sensor with high corrosion resistance, intelligent PID temperature control, dual‑direction operation, and 7-inch touchscreen. It supports real‑time data acquisition and professional software analysis, widely used for determination of melting point, glass transition temperature, polymorphism, enthalpy, oxidation induction time (OIT), crystallinity and specific heat capacity, providing key data for pre-formulation research and quality control of pharmaceutical materials.
DZ-TGA201 Thermogravimetric Analyzer
DZ-TGA201 operates up to 1250 °C with auto-lift furnace, high-precision microbalance and PID intelligent temperature control. It enables accurate measurement of mass change versus temperature, quantifies moisture, crystal water, volatile matter and solvent residues, and analyzes thermal stability, decomposition behavior and reaction kinetics, fully complying with pharmacopoeial requirements for drug stability and impurity testing.
DZ-STA401 Synchronous STA
DZ-STA401 integrates simultaneous TG/DSC detection with auto-lift furnace and three-channel gas control. It acquires heat flow and mass change data in one run, clearly distinguishes physical phase transitions from chemical decomposition, and supports in-depth studies of polymorphism, hydrates, compatibility, degradation pathways and decomposition kinetics.
Covered Drug Categories for Thermal Analysis
Supported by our mature and stable integrated thermal analysis platform, PharmaAnalytica provides customized, full-process analytical services covering a full spectrum of small-molecule drugs, innovative drugs, generic drugs, natural products, biological drugs and pharmaceutical preparations.
- Small-molecule APIs and finished pharmaceutical products
- Innovative small-molecule drugs and generic drugs
- Oral solid preparations, injections and topical formulations
- Natural products
- Biological drugs (proteins, antibodies, peptides)
- Pharmaceutical excipients and raw materials
- Amorphous solid dispersions, liposomes, microspheres and sustained-release preparations
Core Thermal Analysis Services
PharmaAnalytica leverages high-performance DSC, TGA, and STA technologies to provide compliant, standardized full-chain analytical services covering core research links of drug R&D, quality control and registration application.
Pre-formulation Study
Determination of melting point, Tg, thermal stability and purity; polymorphism and hydrate screening; initial drug-excipient compatibility evaluation.
Formulation Development & Process Optimization
Solid dispersion characterization; sustained-release matrix material evaluation; freeze-drying collapse temperature and protective agent screening; coating and tableting process parameter optimization.
Stability & Impurity Analysis
Stress testing, accelerated and long-term stability studies; polymorphism transformation detection; thermal decomposition pathway elucidation; shelf-life prediction.
Quality Control & Regulatory Compliance
Polymorphism consistency testing; moisture and residual solvent quantification; detection of thermal-related indicators; compliant data for registration and release.
PharmaAnalytica is committed to empowering global pharmaceutical innovation with reliable thermal analysis services. Our high-precision platform, combined with automated workflows and compliant operating systems, provides comprehensive solid-state characterization and stability evaluation throughout the drug lifecycle. Adhering to the principles of precision, compliance and efficiency, we support pharmaceutical enterprises and research institutions to accelerate R&D progress, ensure product quality and successfully achieve commercialization.
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