Genomics Platform
PharmaAnalytica's Genomics Platform is a comprehensive, high-throughput sequencing-centric technology ecosystem dedicated to nucleic acid analysis and molecular identification across the entire biopharmaceutical drug development lifecycle. Built around next-generation sequencing (NGS), long-read sequencing, automated nucleic acid preparation, and robust bioinformatics pipelines, the platform enables accurate, sensitive, and scalable genomic characterization for nucleic acid drugs, gene therapy products, biologic candidates, and complex disease targets. By integrating high-performance sequencing and sample-prep instruments with standardized workflows, PharmaAnalytica provides one-stop genomic solutions that drive target discovery, drug candidate validation, quality control, and clinical translation—supporting customers from early discovery through regulatory approval.
Genomics Platform
PharmaAnalytica has built a fully automated, high-precision integrated genomics technology platform dedicated to biopharmaceutical bioanalysis, equipped with high-performance domestic analytical instruments to guarantee standardized, efficient and stable experimental operations.
Npex 192 Automatic Nucleic Acid Extractor
Npex 192 is an ultra-high-throughput, compact, and highly precise instrument that uses advanced magnetic bead-based extraction technology with an 8-matrix deep-well plate layout. It supports extraction for 192 samples in approximately 10 minutes while ensuring minimal magnetic bead residue (≤1%). Equipped with dual functional temperature control modules for lysis and elution (30–120°C), and comprehensive contamination control features including negative-pressure HEPA filtration and UV sterilization, it enables fully automated, closed-tube operation with reliable reproducibility. This instrument is ideal for preprocessing samples for whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RNA-seq), extracting nucleic acids from viruses and gene therapy vectors, as well as preparing samples from blood, tissues, and formalin-fixed paraffin-embedded (FFPE) specimens.
MGISP-100 Library Preparation System
MGISP is a compact, automated workstation dedicated to NGS library preparation. It integrates advanced 8-channel liquid handling with high precision (1 μL–200 μL pipetting range), a comprehensive temperature control system (4°C–90°C), and robust contamination prevention including UV disinfection and HEPA filtration, reducing manual tasks by 90% and ensuring consistent, reproducible results. It supports both DNA and RNA samples with low input requirements and is fully compatible with both short-read and long-read sequencing workflows. This system is primarily used for the automated preparation of next-generation sequencing (NGS) libraries, conducting mRNA and long non-coding RNA (lncRNA) sequencing, constructing full-length libraries for gene therapy vectors, and supporting applications such as non-invasive prenatal testing (NIPT), tumor gene detection, and pathogen identification.
DNBSEQ-T7
DNBSEQ-T7 is a compact benchtop sequencer that provides rapid turnaround times of less than 24 hours and flexible throughput options, making it ideal for small-to-medium-scale research projects and clinical validation applications. This instrument is commonly employed for sequencing gene therapy vectors, verifying CRISPR-mediated gene editing outcomes, identifying full-length plasmid sequences, and conducting quality control and batch release testing for biopharmaceutical products.
DNBSEQ-G400
DNBSEQ-G400 is a versatile benchtop sequencer tailored for medium-to-large-scale genomics projects. It features a dual flow cell system with two interchangeable flow cell types (FCS: 550 million reads; FCL: 1.8 billion reads), supporting flexible output from 550 million to 3.6 billion reads per run and accommodating multiple read lengths including SE35, SE50, SE100, PE50, PE100, PE150, and SE400 to suit diverse research needs. With four independent lanes in the large flow cell, it enables simultaneous sequencing of multiple sample batches to maximize throughput and resource utilization. This instrument is ideal for whole-genome sequencing (WGS), whole-exome sequencing (WES), transcriptome analysis, targeted gene panel sequencing, methylation profiling, and multi-omics research, as well as clinical applications such as cancer mutation detection, pathogen identification, and population genetic studies.
Superiority of PharmaAnalytica's Genomics Platform
Core Applications in Drug Development & Molecular Identification
Focused on genome-level analysis and molecular identification, the platform powers key applications throughout drug R&D:
Target Gene Discovery & Validation
Whole=genome sequencing (WGS), whole-exome sequencing (WES), and RNA-seq enable identification of disease-causing genes, driver mutations, and expression signatures. This supports target prioritization for gene therapy, antisense oligonucleotides (ASOs), siRNA, and CRISPR-based therapeutics.
Gene Therapy Vector Genome Characterization
NGS provides full-length sequence verification of AAV, lentivirus, plasmid DNA, and mRNA constructs, detecting insertions/deletions, mutations, and off-target integration. Critical for vector safety, payload integrity, and batch release.
CRISPR/Cas9 Editing Specificity & Off-Target Analysis
Targeted sequencing and amplicon sequencing precisely assess on-target editing efficiency and genome-wide off-target effects, ensuring safety for gene-editing therapies.
Nucleic Acid Drug Identity & Structural Verification
Sequencing-based molecular identification confirms the full sequence identity, secondary structure, and integrity of LNP-mRNA, circular mRNA, hairpin RNA, and modified oligonucleotides—meeting regulatory requirements for identity testing.
Pharmacogenomics & Drug Response Profiling
Genome‑wide variant detection characterizes drug‑metabolizing gene polymorphisms, supporting individualized therapy design and clinical dosage optimization.
Biomarker Discovery & Companion Diagnostics
Circulating tumor DNA (ctDNA) sequencing, single-cell sequencing, and transcriptome analysis identify predictive and prognostic biomarkers for patient stratification, enabling precision medicine and companion diagnostic development.
PharmaAnalytica's Genomics Platform is a sequencing-driven, fully integrated solution for nucleic acid analysis and molecular identification in drug development. By combining high-throughput short-read sequencing, long-read single-molecule sequencing, automated sample preparation, and robust bioinformatics, it enables comprehensive genomic characterization of targets, vectors, and drug products. Supported by validated instruments and compliant workflows, the platform accelerates discovery, ensures safety and quality, and streamlines regulatory pathways. PharmaAnalytica stands ready to partner with global biotech and pharmaceutical clients to advance nucleic acid drugs and gene therapies, driving innovation and reliability at every stage of development.
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