Proteomics Platform
Proteomics is the large-scale study of proteins, encompassing their expression levels, post-translational modifications (PTMs), structural conformations, and dynamic molecular interactions within cells, tissues, or biological fluids. Proteomics captures the functional, real-time molecular landscape driving biological processes, disease mechanisms, and drug responses. As a cornerstone of modern biopharmaceutical science, proteomics bridges the gap between molecular biology and clinical application, enabling comprehensive analysis of biomolecular interactions that underpin drug efficacy, safety, and mechanism of action.
PharmaAnalytica's Proteomics Platform is a fully integrated analytical ecosystem dedicated to biomolecular interaction and biopharmaceutical analysis, unifying standardized workflows, high-performance instruments, and advanced bioinformatics. Designed to address the full lifecycle demands of drug development—from early target discovery to commercial quality control—the platform delivers precise, reproducible, and traceable proteomic data for small-molecule drugs, recombinant proteins, antibodies, and cell therapy products. It empowers biopharmaceutical developers to unravel molecular mechanisms, validate drug targets, ensure product consistency, and meet stringent global regulatory standards.
Proteomics Platform
PharmaAnalytica's Proteomics Platform follows a streamlined sample preparation → separation → identification → bioinformatics analysis workflow, integrating high-performance instruments at each stage to ensure robustness, and accuracy.
MagicOmics-AP-96 Fully Automated Proteomics Sample Preparation Robot
A high-throughput, walkaway system designed for standardized proteomic sample processing. It integrates automated liquid handling, temperature-controlled incubation, magnetic bead-based purification, and enzymatic digestion, supporting up to 96 samples per batch.
Applications: Protein extraction from cells, tissues, and biological fluids; standardized digestion for LC-MS/MS analysis; high-throughput sample preparation for biomarker discovery and drug-target interaction studies.
Q-TOF MS System LC-QTOF 7000
It delivers ultra-high resolution (>40,000 FWHM), sub-ppm mass accuracy, and a wide dynamic range of 6 orders of magnitude. Equipped with a dual-mode ESI source (compatible with UHPLC and nanoflow LC), a low-dwell-time collision cell, and patented ion valve technology, it achieves high sensitivity while maintaining high resolution. It supports both label-free and labeled (TMT/iTRAQ) quantification, as well as comprehensive PTM analysis (phosphorylation, glycosylation, ubiquitination)
Applications: Global proteome profiling and deep sequencing of complex biological samples; identification and structural characterization of drug-target interaction complexes; quantification of dynamic proteome changes and PTM alterations post-drug treatment; high-resolution analysis of antibody glycosylation, protein aggregation, and degradation products in biopharmaceuticals.
Biolot100 Protein Purification System
A modular, high-performance liquid chromatography (LC) system for protein and peptide separation. Equipped with high-precision PEEK pumps, multi-wavelength UV/Vis detectors, and automated fraction collectors, it supports size-exclusion, ion-exchange, and affinity chromatography. The system complies with FDA 21 CFR Part 11, featuring audit trails and electronic signatures for GMP compliance.
Applications: Purification of recombinant proteins, antibodies, and drug-target complexes; separation of digested peptides for LC-MS/MS; polishing of biopharmaceutical intermediates.
BioLadder Bioinformatics Platform
A user-friendly platform for proteomic data analysis. It integrates industry-standard algorithms (MaxQuant, Perseus, STRING) and supports automated peptide/protein identification, quantification, PTM mapping, and functional enrichment analysis. Dedicated modules enable drug-target interaction analysis, including protein-protein and protein-drug interaction network visualization.
Applications: Raw MS data processing; protein functional annotation; drug-target interaction network construction; biomarker discovery; mechanism-of-action pathway analysis.
Core Testing & Application Services
Biomolecular Interaction Analysis for Drug Discovery
The platform enables comprehensive analysis of biomolecular interactions, accelerating drug discovery and development across key stages:
- Target Discovery & Validation: Identifies disease-associated proteins via differential proteomics (comparing healthy vs. diseased samples). Validates drug-target interactions by capturing and analyzing drug-bound protein complexes, confirming target druggability.
- Drug Mechanism Elucidation: Analyzes proteome-wide changes in protein expression, PTMs, and interaction networks post-drug treatment. Uncovers activated/inhibited signaling pathways, explaining drug efficacy, resistance, or toxicity mechanisms.
- Lead Compound Optimization: Evaluates compound selectivity by profiling off-target binding events. Uses thermal proteome profiling (TPP) to assess target engagement and optimize lead compounds for higher affinity and specificity.
- Biomarker Discovery: Identifies efficacy, safety, and prognostic biomarkers from biological fluids or tissues. Supports patient stratification and companion diagnostic development for personalized medicine.
Biopharmaceutical Analysis
The platform supports end-to-end quality control and characterization of biopharmaceuticals, ensuring safety, efficacy, and regulatory compliance:
- Biologic Structural Characterization: Analyzes primary sequences, PTMs (glycosylation, phosphorylation), and higher-order structures of antibodies, recombinant proteins, and peptides. Detects misfolding, aggregation, and degradation products that impact stability and immunogenicity.
- Purity & Impurity Detection: Quantifies trace impurities, including host cell proteins (HCPs), Protein A leachables, and degradation fragments. Identifies low-level impurities and characterizes their structures to optimize manufacturing processes.
- Stability Assessment: Monitors protein structural changes under stress conditions (temperature, pH, oxidation). Evaluates formulation stability and defines shelf-life for biologic drugs.
- Biosimilar Comparability Analysis: Performs head-to-head proteomic profiling of originator and biosimilar drugs. Compares protein expression, PTMs, and impurity profiles to demonstrate structural and functional similarity for regulatory submissions.
PharmaAnalytica's Proteomics Platform stands as a comprehensive solution that unifies cutting-edge proteomic technologies with robust instrumentation. It delivers unmatched versatility, spanning early drug target discovery, mechanism elucidation, and biopharmaceutical quality control—eliminating workflow silos and streamlining end-to-end analysis. The integration of high-throughput sample preparation, high-resolution Q-TOF MS, and advanced bioinformatics ensures uncompromising accuracy, reproducibility, and traceability, meeting ICH, FDA, and global pharmacopoeia standards. The platform's seamless alignment with biopharmaceutical development workflows—from early molecular validation to commercial quality control—makes it an indispensable tool for accelerating drug innovation, ensuring structural integrity, and driving regulatory compliance in the global biopharmaceutical industry.
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