Metabolomics Platform
Metabolomics is a pivotal branch of systems biology focused on the comprehensive qualitative and quantitative analysis of small-molecule metabolites (typically <1,000 Da) in biological systems, including amino acids, lipids, sugars, organic acids, and hormones. As the most downstream and phenotype-closest layer of the omics cascade, metabolomics directly reflects the real-time physiological and pathological status of cells, tissues, or organisms, capturing dynamic responses to internal and external perturbations such as disease, drug intervention, and environmental stress. Metabolomics reveals the final functional output of biological processes, making it indispensable for deciphering disease mechanisms, identifying biomarkers, and elucidating drug action modes. Its core applications span biomedical research, precision medicine, agricultural science, and pharmaceutical development—particularly in drug target discovery, efficacy evaluation, toxicity assessment, and biopharmaceutical quality control—where it provides critical molecular-level evidence for accelerating R&D and ensuring drug safety.
Metabolomics Platform
PharmaAnalytica has built a full-process, high-throughput metabolomics platform integrating cutting-edge instruments, covering sample preparation, separation, mass spectrometry detection, and bioinformatics analysis. This end-to-end workflow ensures high reproducibility, sensitivity, and accuracy, addressing key bottlenecks in metabolomics research such as sample degradation and low-abundance metabolite detection.
Metabolomics Sample Preparation Workstation
A fully integrated, automated system designed for high-throughput metabolomics sample preparation. It seamlessly combines positive pressure, nitrogen blowdown, liquid handling, heating, shaking, and magnetic separation modules in a single platform. It supports 1–96 samples per batch and accommodates multiple extraction methods, including protein precipitation, solid-phase extraction (SPE), liquid-liquid extraction, and magnetic bead-based purification.
EClassical 3200L Ultra-High-Performance Liquid Chromatograph
A genuine domestic UHPLC system designed for polar and semi-polar metabolites such as amino acids and organic acids. It delivers a maximum pressure of 130 MPa, enabling the use of 1.7–2.5 μm small-particle columns for superior resolution and faster separations.
GC-2000 Gas Chromatograph
Optimized for volatile and derivatized non-volatile metabolites (e.g., fatty acids, sugars). Equipped with a high-sensitivity flame ionization detector (FID) and mass spectrometry interface, it provides excellent separation of isomeric metabolites, widely used in energy metabolism and lipidomics studies.
TQ9100 LC-MS/MS Triple Quadrupole Mass Spectrometer
Dedicated to targeted metabolomics and absolute quantitative analysis. It reaches pg-level ultra-low detection limits and wide linear dynamic range, adopts MRM detection mode, and performs reliably in pharmacokinetic testing, drug metabolite quantification and routine biomarker detection.
Q-TOF MS System LC-QTOF 7000
Ideal for untargeted metabolomics and unknown metabolite screening. It delivers sub-ppm mass accuracy and ultra-high spectral resolution, supports full-spectrum metabolite profiling and novel differential biomarker mining, and accurately characterizes unknown metabolic components.
Core Testing & Application Services
PharmaAnalytica's Metabolomics Platform supports the entire lifecycle of drug development and comprehensive quality characterization of pharmaceuticals through systematic metabolite profiling and pathway analysis.
Drug Research & Development
- Target Discovery and Validation: By comparing differential metabolic profiles between disease and normal samples, the platform screens core dysregulated metabolic pathways and potential therapeutic targets, and verifies target druggability through metabolic response changes after target intervention.
- Drug Mechanism of Action Research: It systematically analyzes metabolic disturbances caused by drug treatment, clarifies how drugs regulate glycolysis, lipid metabolism and other key pathways, interprets therapeutic mechanisms, and identifies potential off-target side effects.
- Pharmacokinetic and Pharmacodynamic Evaluation: It accurately quantifies in vivo drug exposure and metabolite distribution, calculates key PK parameters, and screens sensitive pharmacodynamic biomarkers to guide clinical dosage optimization and efficacy monitoring.
- Preclinical Drug Safety and Toxicology Assessment: The platform screens early predictive biomarkers of liver and kidney toxicity, reveals metabolic disorder mechanisms induced by adverse reactions, and reduces safety risks in subsequent clinical trials.
- Precision Medicine Biomarker Development: It screens disease diagnosis, efficacy prediction and prognosis-related metabolic markers, supporting patient stratification and individualized precise medication regimens.
Pharmaceutical Analysis
- Fermentation Process and Raw Material Quality Monitoring: It analyzes amino acids, sugars and by-product metabolites in biopharmaceutical fermentation systems, optimizes production processes, stabilizes fermentation yields, and ensures consistent raw material quality between batches.
- Biologic Drug Purity and Impurity Characterization: The platform identifies small-molecule degradation products, process-related impurities and abnormal metabolic by-products of protein drugs, comprehensively evaluating product purity and safety attributes.
- Drug Stability and Formulation Optimization: It tracks metabolite changes under high temperature, oxidation and other stress conditions, clarifies drug degradation pathways, and optimizes prescription formula and long-term storage conditions.
- Microbial Contamination and Safety Inspection: It detects characteristic metabolites of microorganisms and endotoxin-related small molecules, effectively controlling microbial safety risks of biopharmaceutical preparations.
- Biosimilar Comparability Evaluation: It conducts metabolic fingerprint comparison between reference drugs and biosimilars, verifying consistency in molecular metabolism and functional characteristics to assist regulatory declaration and market approval.
PharmaAnalytica's Metabolomics Platform builds a full-chain, standardized analytical system relying on high-performance instruments. Integrating targeted quantitative detection and untargeted full-spectrum screening, the platform covers almost all mainstream endogenous metabolites and exogenous drug metabolites, with ultra-high sensitivity capable of capturing trace metabolic changes induced by slight drug interference. The platform perfectly connects early drug mechanism research, preclinical safety evaluation and commercial biopharmaceutical quality control, realizing one-stop integrated metabolomic services. Combined with professional customized bioinformatics interpretation, it greatly shortens drug research and development cycles, improves research efficiency, and becomes an irreplaceable core analytical platform for innovative drug development and biologic drug quality supervision in the global biopharmaceutical industry.
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