Electrophoretic Analysis Platform
The Electrophoretic Analysis Platform is a high-resolution, multi-technique separation system dedicated to pharmaceutical quality control, biologic characterization and impurity profiling. It integrates gel electrophoresis, capillary electrophoresis (CE), isoelectric focusing (IEF) and supporting imaging techniques, each with distinct strengths tailored to specific analytical needs. The following table summarizes their core advantages and typical pharmaceutical applications for clear comparison.
| Technology Type | Core Advantages | Applicable Scenarios |
| SDS-PAGE | Low cost, easy operation, high throughput, accurate molecular weight estimation |
|
| Agarose Gel Electrophoresis | Fast separation, simple sample prep, clear nucleic acid bands |
|
| Isoelectric Focusing (IEF) | High resolution for charge variants, accurate pI determination |
|
| Capillary Electrophoresis (CE) | Ultra high resolution, minimal sample volume, fully automated, pharmacopoeia compliant |
|
Electrophoretic Analysis Platform
PharmaAnalytica's Electrophoretic Analysis Platform unifies gel electrophoresis, capillary electrophoresis (CE), isoelectric focusing (IEF) and supporting imaging & sample preparation modules. It enables precise separation, identification and quantitation of proteins, nucleic acids, peptides and small-molecule drugs, meeting the stringent separation and purity testing requirements of biopharmaceutical research and regulatory compliance.
Gel Electrophoresis System
This integrated system consists of a vertical SDS-PAGE unit, a horizontal agarose gel unit and a gel imaging & analysis system, forming a comprehensive solution for routine biopharmaceutical quality control, covering protein and nucleic acid analysis. It is widely applied for protein purity, molecular weight and impurity profiling of monoclonal antibodies, recombinant proteins and fusion proteins, as well as batch consistency evaluation. It also supports DNA/RNA integrity and purity testing, plasmid supercoiled ratio analysis and residual host nucleic acid detection for vaccines and cell therapy products. The integrated imaging system enables accurate band quantification, molecular weight calculation and traceable data archiving for regulatory submission.
iCE280 ADVANCE Isoelectric Focusing (IEF) System
A high-precision iCIEF system for biopharmaceutical charge heterogeneity analysis. iCE280 ADVANCE integrates a 280 nm LED module, high-resolution CCD camera and transparent capillary column, enabling whole-column imaging without mobilization for improved stability and reproducibility. It excels at analyzing mAbs, recombinant proteins, fusion proteins, PEGylated proteins, glycoproteins, and high-molecular-weight protein complexes/viruses, supporting pI determination, charge variant profiling and batch consistency evaluation. Compliant with 21 CFR Part 11 and pharmacopoeia standards, it meets biopharmaceutical QC and R&D needs.
CE-1000 Capillary Electrophoresis (CE) System
A high-performance capillary electrophoresis platform supporting CE-SDS, cIEF and CZE separation modes. Equipped with a 0–30 kV precision high-voltage power supply, temperature-controlled capillary cartridge and UV detector. It delivers high-resolution separation for antibody size variants, charge isoforms, glycans, chiral impurities and API purity, meeting pharmacopoeia requirements as a modern alternative to traditional gel electrophoresis.
2D-PAGE Electrophoresis System
This integrated solution is composed of DYCZ-26C two-dimensional electrophoresis instrument and Chemi Dog Ultra fully automatic multi-functional imaging system. It achieves high-efficiency protein separation through first-dimensional isoelectric focusing and second-dimensional molecular weight separation. Matched with high-sensitivity imaging and quantitative analysis functions, it is widely applied in differential expression analysis of complex protein samples, host cell residual protein screening and overall impurity spectrum identification of biological products. It provides reliable technical support for biopharmaceutical impurity research, process optimization and quality consistency assessment.
Core Electrophoretic Analysis Services
Protein Drug Purity & Integrity Analysis
- Purity profiling of mAbs, recombinant proteins and ADCs
- Detection of aggregates, fragments and process‑related impurities
Nucleic Acid & Plasmid Quality Control
- Plasmid integrity and supercoiled ratio analysis
- Residual host DNA/RNA detection for vaccines and cell therapy products
Charge & Size Heterogeneity Characterization
- IEF-based pI profiling
- CE-SDS size variant analysis
- Glycoform and post-translational modification assessment
Small-Molecule & Peptide Drug Quality Testing
- API purity, chiral impurity and counter-ion analysis
- Peptide mapping
- Batch consistency verification
Biologic Impurity & Residual Substance Monitoring
- Residual host protein, protein A and process-related impurity detection for biologic safety evaluation
PharmaAnalytica's Electrophoretic Analysis Platform provides comprehensive separation and characterization capabilities for biologic drugs, nucleic acid products and small-molecule pharmaceuticals. Equipped with high-precision instruments, standardized workflows and compliant data management, it delivers accurate, traceable and regulatory-ready results to support biopharmaceutical R&D, quality control and global registration.
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Need More Information or Request A Quotation?
Related Links
