NMR Platform
Nuclear Magnetic Resonance (NMR) spectroscopy is a non-destructive, label-free analytical technology that leverages magnetic fields and radiofrequency pulses to detect nuclear spin resonance signals in samples. By analyzing these signals, NMR enables comprehensive characterization of molecular structures, conformations, dynamics, and intermolecular interactions—without damaging samples or introducing external labels. As a gold standard for structural analysis, NMR plays an indispensable role in biopharmaceutical R&D and quality control, supporting drug structure confirmation, purity assessment, impurity profiling, and mechanism elucidation.
NMR Platform
PharmaAnalytica's NMR Platform is a fully integrated analytical ecosystem dedicated to structural characterization for biopharmaceuticals, unifying advanced NMR technologies, high-performance instruments, and standardized workflows. Designed to address the full lifecycle demands of drug development—from early-stage structure elucidation to commercial quality control—the platform delivers precise, reproducible, and traceable structural data for small-molecule drugs, peptides, proteins, and biologic therapeutics. It bridges the gap between basic structural research and industrial application, empowering biopharmaceutical developers to ensure molecular consistency, verify structural integrity, and meet stringent global regulatory standards.
CAN600 Nuclear Magnetic Resonance Spectrometer
CAN600 is a intelligent liquid-state NMR spectrometer equipped with an ultra-homogeneous, ultra-shielded 600 MHz superconducting magnet (14.1 Tesla). It features a high-sensitivity automatic tuning probe supporting multi-nucleus detection (¹H, ¹³C, ¹⁵N, ³¹P, ¹⁹F) and dual-channel decoupling experiments. The distributed cabinet design supports up to 8 independent transceive channels with ultra-high frequency/time resolution. A 72-position auto-sampler enables second-level sample exchange, while an intelligent touchscreen allows direct instrument control and status monitoring. With bilingual AI-powered software and remote diagnostics, it ensures high efficiency and reliability. It is widely used for small-molecule drug structure confirmation, stereochemistry analysis, impurity identification, and quantitative analysis of pharmaceutical intermediates.
Quantum 600MHz NMR Spectrometer
Quantum 600MHz features a 600 MHz (14.09 T) ultra-shielded superconducting magnet with high magnetic field uniformity and stability, integrated with high-speed magic angle spinning (MAS) probes (up to 70 kHz) and multi-channel RF systems supporting ¹H, ¹³C, ¹⁵N, ³¹P, and ¹⁹F detection. With precise temperature control (–180°C to 180°C) and advanced solid-state 2D correlation experiments (e.g., CP/MAS, HETCOR), it enables high-resolution characterization of drug polymorphs, crystal packing, amorphous structures, and excipient–drug molecular interactions. It is widely used for polymorph identification, amorphous stability assessment, solid-form transition monitoring, and quality control of oral solid formulations and sustained-release preparations.
Core NMR Analysis Services
Structure Confirmation & Stereochemistry Analysis
Delivers definitive confirmation of molecular structures, including functional group identification, bond connectivity, and stereochemical configuration (e.g., chiral centers, geometric isomers). By analyzing 1D/2D NMR spectra, it verifies the structural consistency of synthetic drugs, intermediates, and natural product-derived therapeutics, ensuring compliance with regulatory requirements for identity and purity.
Drug Purity & Impurity Profiling
Enables non-destructive, label-free quantification of drug purity and qualitative identification of trace impurities, degradation products, and residual solvents—without requiring reference standards. It detects low-level impurities (≤0.1%) and characterizes their structures, supporting stability studies, degradation pathway elucidation, and process optimization to minimize impurity formation.
Polymorph & Solid-Form Characterization
Analyzes drug polymorphs, amorphous forms, salts, and cocrystals, which directly impact drug solubility, dissolution rate, stability, and bioavailability. It distinguishes different solid forms, quantifies polymorphic purity, and monitors solid-form transitions under stress conditions (temperature, humidity), guiding formulation design and storage condition optimization.
Biopharmaceutical Higher-Order Structure Analysis
For proteins, peptides, and antibody therapeutics, NMR characterizes secondary/tertiary structures, folding integrity, and conformational dynamics under native conditions. It assesses structural stability during production, formulation, and storage, detects misfolding or aggregation, and verifies the structural consistency of biosimilars relative to reference products.
Drug-Target Interaction & Mechanism Elucidation
Analyzes the binding affinity, binding sites, and conformational changes of drug-target complexes (e.g., small molecule-protein, peptide-receptor) under physiological conditions. It maps drug binding epitopes, elucidates molecular mechanisms of action, and supports rational drug design and lead optimization by validating target druggability.
Biosimilar Comparability & Regulatory Compliance
Performs head-to-head structural comparison of originator and biosimilar drugs, analyzing primary sequences, higher-order structures, post-translational modifications, and impurity profiles. By demonstrating structural similarity, the platform supports regulatory submissions, approval, and market access for biosimilars, meeting ICH and pharmacopoeia requirements.
PharmaAnalytica's NMR Platform delivers unmatched versatility, spanning small-molecule structure elucidation, solid-form characterization, and biologic higher-order structure analysis—eliminating silos and streamlining structural workflows. The platform's seamless alignment with biopharmaceutical development workflows—from early structural validation to commercial quality control—makes it an indispensable tool for accelerating drug innovation, ensuring structural integrity, and driving regulatory compliance in the global biopharmaceutical industry.
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